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Bisacodyl
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| Systematic (IUPAC) name | |
| [4-[(4-acetyloxyphenyl)-pyridin-2-yl-methyl]phenyl] acetate | |
| Identifiers | |
| CAS number | |
| ATC code | A06 |
| PubChem | |
| Chemical data | |
| Formula | C22H19NO4 |
| Mol. mass | 361.39 |
| Pharmacokinetic data | |
| Bioavailability | 15% |
| Metabolism | Hepatic CYP450 |
| Half life | 16 Hours |
| Excretion | primarily in the faeces, systemically absorbed drug is excreted in the urine |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status |
OTC |
| Routes | Oral, Rectal |
Bisacodyl (INN) is a stimulant laxative drug. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction. Bisacodyl is a diphenylmethane derivative and was first used as a laxative in 1953 due to its similarity to phenolphthalein [1].
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Bisacodyl is sold under the trade names Dulcolax, Fleet, Alophen, Correctol, Carter's Little Pills as well as generically. It is usually sold as 5mg tablets, 10mg suppositories, or 5mg pediatric suppositories.
When bisacodyl is administered orally, it is usually taken at bedtime, but when it is administered rectally, it is usually taken in the morning. This is due to the relatively long onset of the drug when taken orally (around 6-10 hours) compared to when it is taken rectally (around 15-60 minutes). This drug is often used by people suffering from bulimia nervosa. The largest amount of this drug known to be taken at one time and not to cause any serious health disorders is 180 5mg tablets (the total amount of drug intake equal to 900mg). Bisacodyl is also sometimes used before and after a colonoscopy.[1]
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